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A "natural" origin of a substance tells you nothing about overall safety at a synthetic dose, by an unphysiological route, in a manufactured form whose purity is not independently verified
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Our data, consistent with the literature [32], show that chronic duration of therapy, higher cumulative metformin dose and concomitant PPI therapy (Table 1) increase the risk of vitamin B 12 deficiency
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If you consider dose cycling, do it under medical supervision
