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Freckles result from melanin accumulation on the skins outer layer due to sun exposure

doi: 10.1111/j.1469-7793.1998.565bn.x

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Metabolic and glucose regulation : Berberine has been studied for its effects on blood glucose control, with some research suggesting it may improve insulin sensitivity and reduce fasting blood glucose levels through AMPK activation

Your body is going to produce melanocytes that go into the hair follicle and they actually get pushed into the hair strand as it's grown. For this reason, Small stresses that Arey and products like it should be used as a preservation step, rather than a Hail Mary on white hair