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Yes continuous use beyond 4 weeks triggers IGF-1 receptor downregulation regardless of dose

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Assessment of requirements for selenium and adequacy of selenium status: A review

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Abbreviations 5mC, 5-methylcytosine

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Thus, the IGF-1 signaling is essential for processes such as cell proliferation, survival, and metabolic regulation, impacting various organs and systems

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doi: 10.1016/j.biomaterials.2009.11.067 271 HanJYunJQuanMKangWJungJ-GHeoWet al

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