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A 2015 review published in Oxidative Medicine and Cellular Longevity documented GHK-Cus capacity to reset gene expression patterns in aged human fibroblasts to patterns characteristic of younger cells a result that Matrixyls single-signal mechanism cannot replicate

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doi: 10.1186/s13578-023-01031-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 199.Bousset L, Gil J

Subsequent studies established this activity as a tripeptide with an amino acid sequence glycyl-L-histidyl-L-lysine with a strong affinity for copper that readily formed the complex GHK-Cu