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Busulfan with having two methanesulfonate groups, attached to two ends of a butane chain, hydrolyzes and releases extremely reactive positively charged carbonium ions, which react with the guanine molecules in cell's DNA, resulting in DNA interstrand crosslinks

[DOI] [PubMed] [Google Scholar] Siemes H, Nau H, Schultze K, Wittfoht W, Drews E, Penzien J, Seidel U

SPCD has many variations in its presentation, from asymptomatic over metabolic crises at young age (sudden infant death syndrome, episodes of hypoglycemia, and Reye-like syndrome) to progressive cardiomyopathy [4]

doi: 10.1200/JCO.2012.44.8738 [DOI] [PMC free article] [PubMed] [Google Scholar] 38.Campone M, Berton-Rigaud D, Joly-Lobbedez F, et al

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