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A systematic review of histone lysine-specific demethylase 1 and its inhibitors

Journal of Diabetes Mellitus, 2012

Modulators that induce mitochondrial hormonal responses promote mitochondrial adaptation and resilience by mimicking sublethal stress (e.g., mild oxidative or caloric stress), thus activating the cellular protective stress response

In addition, we highlight its role in driving metastatic progression, underscoring its dual influence on treatment failure and tumor dissemination

This process is particularly important for the normal functioning of the heart and brain which require significant amounts of energy
