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Additional proteins and lipids within ISGs (e.g., mannose-6-phosphate receptor, carboxypeptidase D, and Golgi-associated -ear-containing ARF-binding protein) are selectively removed via clathrin-coated vesicles and recycled back to the TGN via retrograde trafficking or to another compartment (e.g., endosomes) via anterograde trafficking

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We found significant differences between children with ASD and control children regarding studies measuring plasma methionine, serum vitamin B9, serum vitamin D, and plasma GSH levels (eFig