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NADPH is involved in the cycling of the GPX4 antioxidant system, and its depletion limits the antioxidant function of GSH-GPX4, inducing ferroptosis [56, 57]

Methods Generation of isogenic knockout lines Human iPSCs were cultured in standard conditions, and before nucleofection cells were pre-treated for 1 h

Naryan et al

Viral protein nsp7 could potentially alter host lipid metabolism, through its avid interaction with host enzymes involved in FA-oxidation and lipogenesis 42