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Description
In response to oxidative challenges, Nrf2 dissociates from its inhibitor, Kelch-like ECH-associated protein 1 (Keap1), moves to the nucleus, and binds to the antioxidant response element (ARE) to activate the Nrf2-dependent antioxidant system
J Am Soc Nephrol 2003;14:18251832
Similar improvements in seminiferous tubule integrity, germinal epithelium thickness, and the density of spermatogenic cells following PRP injection have been consistently reported across multiple studies [40, 70,71,72]
In this study, CS NPs were selected as a delivery vehicle based on their well-documented propensity for renal accumulation, attributed to their positive surface charge and affinity for negatively charged glomerular and tubular membranes [36, 37]
10.1016/j.cell.2018.06.025 46 Redondo-MuozM.Rodriguez-BaenaF
