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This is because there is a competitive need for glutathione (GSH) to be used: 1) to clear H 2 O 2 , a byproduct of oxidative stress [10] , and, 2) to enable the detoxification of formaldehyde [17]

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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

Tamayo M, Agusti A, Molina-Mendoza GV, Rossini V, Frances-Cuesta C, Tolosa-Enguis V, et al

doi: 10.1056/NEJMoa0808431 106 KhdourMR