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#CNSBiotech #Biotech #DrugDiscovery #PreclinicalResearch #TranslationalMedicine #HumanRelevantModels #PreclinicalModels #Neuroscience #CNSDrugDevelopment #RAndD #DrugDevelopment #NC3Rs To view or add a comment, sign in Synaptic plasticity isn't just a mechanism it's a therapeutic target

These studies provided the rationale for testing cagrilintide in humans, both as a single agent and in combination with GLP-1 analogues, to harness the enhanced weight-lowering effect observed in animals

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HEK-293 cells HEK-293 cells (ATCC, CRL 1573 TM ) were cultured in high glucose DMEM media (Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario) at 20% O 2 at 37 C to a confluency of 6080%