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Smaller nanoparticles (typically less than 100 nm) are more likely to pass through the BBB because they are more easily taken up by brain endothelial cells (Nowak et al., 2020)

Combination therapy allows simultaneous targeting of multiple therapeutic genes, and is currently the most effective treatment for aggressive tumors, such as GBM ( 10.1 Disulfiram in combination with metal supplements Preclinical and clinical studies have shown that DSF has broad-spectrum anticancer activity against a variety of cancer types when combined with Cu-containing supplements, such as Cu gluconate (McMahon et al., 2020)

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The dose is escalated over approximately 16 weeks following a protocol similar to Wegovy's escalation schedule

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