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The likelihood of developing peripheral neuropathy increases with multiple treatment courses, use of combination chemotherapy and higher doses

Lioudaki 2011)

Immortalized hepatoma cell lines, such as L-02, derived from normal embryonic liver cells and Huh-7 (a well differentiated cell line derived from a human carcinoma) have also been used

Consequently, ATP7A is responsible for exporting copper from the intestines, while ATP7B facilitates copper export from the liver

Given the challenge of the undruggable properties of Rho GTPases and the intricate downstream signaling pathways, current strategies for Cdc42 inhibition primarily focus on obstructing interactions with guanine nucleotide exchange factors (GEFs) or inhibiting nucleotide binding [45]