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The widely used human in vitro model is the THP-1 cell line, which is derived from leukemic monocytes and can be differentiated into macrophages

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Tardiolo G., Bramanti P., Mazzon E

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Originally isolated from the brain, DSIP is of particular interest in research on sleep patterns, circadian rhythm modulation, and stress adaptation mechanisms

In vitro experiments suggest that this secondary pyroptosis is mediated by Gasdermin-E, instead of Gasdermin-D [328]