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Clinical & Experimental Metastasis, 27(2), 83-90

518 This protective function of CLPP may serve as an important supplementary mechanism to mitophagy in clearing ROS-damaged mitochondria

It is well known that morphine can markedly lower GSH and cysteine levels in brain and peripheral tissues 109,110,111,112,113,114,115,116,117

Similarly, in animal models, the combination of curcumin and paclitaxel significantly increased tumor suppression rates and prolonged the survival of mice (Petrova et al., 2023)

Each copper domain is thought to have a distinct function, with Cu H transferring electrons from its co-substrate ascorbic acid, and, in the process, generating superoxide, with Cu M hydroxylating substrates (Brenner & Klinman, 1989