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To date, well over twenty different peptides have been studied and assessed for their ability to make a meaningful impact in the bone remodeling process
Among several AKR inhibitors tested against AKR1B15, only JF0064 significantly inhibited AKR1B15 while potent inhibitors of AKR1B1 and AKR1B10 such as tolrestat, epalrestat, sulindac, and sorbinil failed to inhibit AKR1B15
(2015) 149:R21927
J Korean Neurosurg Soc (2018) 61(4):441-9
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