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Important safety information includes a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings for pancreatitis, gallbladder disease, acute kidney injury, and hypoglycemia risk when used with insulin or sulfonylureas

Theranostics 10(26): 11921-11937

Liraglutide, sold as Victoza and Saxenda, treats similar conditions

Additionally, L-5-MTHF works synergistically with methylcobalamin to lower the toxic burden of homocysteine in the vasa nervorumthe tiny blood vessels that supply oxygen and nutrients to the peripheral nerves
