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Differences in stimulation regimens, progesterone exposure timing, sampling windows, culture media formulation, incubator conditions, and operator-dependent handling can generate centre-specific signatures that mimic biology in single-site studies but weaken or invert in external cohorts [461, 462, 482, 483]

Although not found in a chain, an additional FeS cluster found within Complex III plays an integral role in passing electrons from ubiquinol (the reduced version of ubiquinone) to cytochrome c , to facilitate further transfer of electrons to Complex IV

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