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2014;9(10):e108788

(Checa and Aran, 2020)

Oxidative stress in thyroid hormone synthesis: a review

For example, the prodrug and cancer chemotherapeutic agent irinotecan is a camptothecin analog that is bioactivated by plasma and intracellular carboxylesterases to SN-38 ( Figure 65 ), a potent inhibitor of topoisomerase 1
Also referred to as Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX), GPX4 is unique in its monomeric structure and high affinity for lipid hydroperoxides [20, 21]