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Gamma-aminobutyric acid, as an inhibitory neurotransmitter, can counteract the excitotoxic effects of glutamate and enhance neuronal tolerance to ischemia 29

GHK-Cu is compatible with most cell culture media but may interfere with BCA protein assays due to copper interference with the assay chemistry

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While the Fe-S cluster is critical for activity, its role for the reaction mechanism remains unclear (Carroll et al., 2005)

A coordinated induction in the activity of both enzymes would further enhance GSH synthesis capacity