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273 However, in a recently reported study, treatment of dialysis patients with peginterferon alfa-2a (135 g per week) and low-dose ribavirin (200 mg/day) led to an SVR in 29% of HCV monoinfected patients (one-half with genotype 1) and in one-third of those coinfected with HIV

[32] with minor modifications for use in mouse brains

Cultures should not be discarded as negative until after 7 days of incubation

They observed that introducing ester, carbamate, or thioether linkages to the ionizable lipids led to a substantial reduction in the in vivo activity compared to LNPs containing DLinDMA