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Finally, phosphorylated MLKL oligomerizes and translocates to membrane to elicit cell lysis, which eventually leading to the release of intracellular content and necroptotic cell death [75, 96, 97]

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JCI Insight 4 (17), e129920

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6,19,55-58 The diagnostic criteria for NCM currently accepted are those of Kadonaga & Frieden: 58 Presence of one GCMN or three or more CMN, associated to meningeal melanosis or meningeal melanomas

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When this set of Maillard reactions takes place in vivo, they are known as non-enzymatic glycosylation or simply glycation , and they lead to the formation of a heterogeneous set of compounds known as advanced glycation end-products (AGEs)

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