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Hepatology 32:455460 Mayo JC, Sainz RM, Tan DX, Hardeland R, Leon J, Rodriguez C, Reiter RJ (2005) Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK) in macrophages

The data related to these biomarkers need to be validated in future studies, followed by testing of their clinical utility for routine screening, as non-surgical diagnostic markers, and as targets for immunomodulatory therapy, with the aim of identifying immunomodulatory strategies for this disease

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doi: 10.1021/bi7000032 118 ButterfieldDABoyd-KimballD

Production of reactive oxygen species (ROS) was monitored following 5-(and-6)-chloromethyl-2,7-dichlorodihydrofluorescein diacetate acetyl ester and MitoSOX Redderived fluorescence
