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In buccal and sublingual delivery, niosomes perform best when they are incorporated into dosage forms such as films, gels, or sprays that form thin films in the mouth, since simple suspensions are easily washed away by saliva and may be swallowed

Compared with standard glutathione (500 mg), LipoMicel at a lower dose (300 mg) increased iAUC and C max by ~2.49-fold and ~2.43-fold, respectively, and when dose-normalized (to a 300 mg equivalent), incremental systemic exposure and peak levels were up to ~4-fold higher, supporting greater absorption per unit dose. The findings indicate LipoMicel is a promising delivery method for oral glutathione, though the researchers added larger, long-term studies are still needed

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They found that glutathione absorption from oral mucosa massively and rapidly increased serum concentration

They both speed up skin cell turnover and can overdo the exfoliation thing