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Presterud, R., Deng, W

Each peptide is associated with different biological mechanisms

Physiologically, NRF2 is predominantly sequestered in the cytoplasm through its association with Keap1, which acts as an adaptor to oxidative or electrophilic stressors, such as elevated ROS, conformational changes in Keap1 disrupt its interaction with NRF2, leading to NRF2 stabilization and release (Yamamoto et al., 2018)

Strategies for targeting intestinal fungi in the treatment of CLDs New therapies based on the fungal community, such as dietary intervention, FMT, probiotics (including fungal and bacterial strains), and antifungal drugs, have shown significant effects in regulating the intestinal fungal community and restoring imbalanced immune homeostasis by re-establishing the core intestinal fungal community 13,154,155,156