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doi: 10.1172/JCI111347 31 LeungKCDoyleNBallesterosMWatersMJHoKK

Crohns Colitis 17 , 17331743 (2023)

Another notable limitation is the potential risk of bias in the included studies

Notably, NRF2-inducing compounds, such as tBHQ and sulforaphane, modify distinct KEAP1 residues from oxidation by ROS, thus allowing for an additive effect in the presence of oxidative stress (Suzuki et al., 2019

HRW has been shown to mitigate renal injury by inhibiting key signaling pathways, including PI3K/AKT, NFB, and TGF [48]