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Abbreviations ALT Alanine aminotransferase AST Aspartate aminotransferase BMI Body mass index CAP Controlled attenuation parameter FBS Fasting blood sugar HbA1c hemoglobin A1c HDL High-density lipoprotein IRI Immunoreactive insulin LDL Low-density lipoprotein LSM Liver stiffness measurement NAFLD Nonalcoholic fatty liver disease NASH Nonalcoholic steatohepatitis NEFA Non-esterified fatty acid UMIN University Hospital Medical Information Network VCTE Vibration-controlled transient elastography Authors contributions Designed and coordinated the study: TK, YH, YS, and AN

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Comparative flow cytometric analysis of MZB (CD19 + CD23 low CD21/35 high ) and FoB (CD19 + CD23 high CD21/35 low ) in Gclc fl/fl Mb1-Cre + and control mice showed that Gclc deletion caused a stark decrease in MZB but not in FoB (Fig

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