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It helps support the normal formation of red blood cells, healthy nerve function, and energy metabolism, making it an essential treatment for patients with confirmed B12 deficiency

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Hence, clinicians should correct vitamin B12 deficiency in patients treated with metformin following the British Society for Haematology guidelines for diagnosis and treatment of vitamin B12 deficiency[62]

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SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

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