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Importantly, accumulating evidence suggests that the relative balance between E2 and P4and not only their absolute circulating concentrationsmay act as a key determinant of phase-specific metabolic phenotypes [47,48], particularly in skeletal muscle, liver, and adipose tissue [49,50]

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DNMT1 is highly expressed in immune cells and has been shown to play a role during hematopoiesis (266) and lymphocyte development (267, 268)

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