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A consistent imbalance in GSH and GSSG has been observed in asthma

Supporting this hypothesis, a chronic unpredictable mild stress mouse model demonstrated that melatonin effectively restored aquaporin-4 polarization and rectified the compromised glymphatic system observed in this model [215]

These adaptations reflect neuroplastic remodeling of pain circuits rather than restoration of tissue integrity

doi:10.1089/ars.2011.4454 Jones DP, Mody VC Jr, Carlson JL, Lynn MJ, Sternberg P Jr (2002) Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses