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For observational studies (cohort and case-control), the NewcastleOttawa Scale (NOS) (La Torre et al., 2014), was applied

Do not assign both without clear documentation of co-existing distinct conditions

Like most treatments, vitamin B12 injections carry warnings that patients should be aware of, including: Hereditary Optic Nerve Atrophy: People with early Lebers disease (a hereditary form of optic nerve atrophy) should not receive cyanocobalamin injections, as rapid and severe vision loss has occurred

Injections work faster, while supplements take longer but are more convenient and affordable

Metabolic applications