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In vitro , sapitinib increased the intracellular accumulation of [ 3 H]-paclitaxel in SW620/Ad300 cells compared to SW620/Ad300 cells incubated with the vehicle and to the parental SW620 cell, which do not overexpress the P-gp transporter
doi: 10.1152/ajplung.00081.2007
In vitro studies suggest that AX has the potential to protect against liver steatosis by preventing fat accumulation in hepatocytes [866,867], It has been reported that AX may reduce hepatic lipid accumulation by modulating the activity of nuclear receptors PPAR- and PPAR- in a favorable manner, acting as a PPAR- agonist and a PPAR- antagonist, respectively [866]
Cell Survival Responses to Environmental Stresses via the Keap1-Nrf2-ARE Pathway
Topical N-Acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo
