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A notable subset of patients with MCAS or specific genetic variants (such as CBS gene mutations) have impaired transsulfuration pathways or severe sulfur sensitivities

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Pregnancy and lactation safety has not been systematically studied, and as with most cosmetic and research compounds lacking definitive pregnancy safety data, conservative practice typically suggests avoiding use during pregnancy unless clearly needed, though the natural occurrence of GHK-Cu in the body and minimal systemic absorption from topical use suggest risk is likely to be low

You might be asked to continue with this treatment for a period after becoming pregnant and should be used as prescribed for it to be effective

10.1021/acs.accounts.8b00254 58 WangM.LiX.HeF.LiJ.WangH