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710 Cuproptosis represents a metal-dependent RCD defined in 2022, in which intracellular copper binds to lipoylated tricarboxylic-acid (TCA) cycle enzymes, most notably dihydrolipoamide S-acetyltransferase (DLAT), driving protein oligomerisation/aggregation, loss of FeS-cluster proteins, and mitochondrial proteotoxic stress in cells reliant on oxidative phosphorylation

The energy sensor AMPK regulates T-cell metabolic adaptation and effector responses in vivo

For patients who want to combine the two, the injection cadence is manageable

Moreover, it is also recorded that various environmental pollutants/toxicants can trigger the complex process of inflammation, leading to the induction of oxidative stress in various systems of exposed living organisms [40]