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CB: Writing original draft, Data curation

Anticancer Drugs 31 , 2734 (2020)

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The pharmacological actions of M6G [90] might be of particular relevance, as indicated by their high efficacy at MOP located in the locus coeruleus [111], where opioid-induced long-term neuronal inhibition is an important contributor to the development of tolerance [232, 233]

Mrp1 is highly expressed in the intestine and certain other organs such as liver (Cherrington et al., 2002), however, the expression level of Mrp1 varies between rats
