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Second, ROS and mitochondrial DNA (mtDNA), as damage-associated molecular patterns (DAMPs), along with pathogen-associated molecular patterns (PAMPs), may activate the NLRP3 inflammasome and induce the release of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, potentially transforming localized metabolic stress into a systemic inflammatory response

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10.1039/b914751a Pubmed Abstract CrossRef Google Scholar View reference in article 30

In a trial involving 77 individuals with a body mass index of 25 kg/m 2 or higher (age = 53.2 0.7 years), eight weeks of supplementation with lions mane extract led to significant improvements in depression (29.4%), anxiety (33.2%), and sleep disorders (39.1%) compared to baseline

By enhancing the bodys natural growth hormone release, CJC-1295 may help support metabolism, muscle maintenance, recovery, and overall vitality as we age