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The translocation of the mitochondrial pyruvate dehydrogenase complex to the nucleus also facilitates the nuclear production of acetyl-CoA necessary for histone acetylation 88

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doi: 10.1161/CIRCULATIONAHA.118.035869

(2018), incorporated haptoglobin genotyping based on preliminary data showing that 65.71% of Chinese NAFLD patients carry the Hp 22 genotypesubstantially higher than the 36% observed in Western populationssuggesting that Chinese patients may derive enhanced benefit from VE therapy due to this genetic predisposition