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Glycyrrhizin is metabolized in the intestine to glycyrrhetinic acid and undergoes enterohepatic circulation

Other enzymes, such as AARS and alpha-tubulin ACT1 (ATAT1) have also been found to play a role

It also evaluates their use for encapsulating pharmacological drugs such as dopamine agonists, dopamine precursors, COMT inhibitors, and MAO-B inhibitors, addressing the limitations of conventional therapies

10.1038/jidsymp.2008.3 11 BolkeL.SchlippeG.GerJ.VossW

Consequently, direct investigations within AD models and patient cohorts are essential to validate the precise mechanistic role of DNA methylation in regulating ferroptosis during neurodegeneration