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Key finding: NNMT overexpression drives satellite cell senescence pharmacological inhibition with 5-Amino-1MQ restored stem cell activation to levels comparable to young animals
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at the cellular level this reprograms metabolic signaling (e.g., sirtuin-dependent pathways) and has been shown in vitro and in rodent studies to lower 1-MNA , reduce adipocyte lipogenesis/size , and increase energy expenditure
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