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In addition to intestinal mobility, it has become evident that peripheral serotonin participates in systemic energy homeostasis ( 2 as co-substrates, and has ferrous ion (Fe 2+ ) as an activator

doi: 10.1158/1541-7786.MCR-16-0480 77 WangQHardieRAHoyAJvan GeldermalsenMGaoDFazliLet al

In particular, BHB, in addition to its role as an energy source, also has a variety of molecular signaling and regulatory functions in a wide range of human diseases ( 4.1 Epigenetic regulation BHB has been reported as a Class I histone deacetylase (HDAC) inhibitor and an endogenous neuroprotective epigenetic modifier ( 4.2 Gut microbiome Gut microbes are also known to be involved in the development of many diseases