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Multiple studies including Caucasian and Asian patients have shown that combination therapy with 2% KA and hydroquinone improves melasma

Colorectal cancer metastasis to the liver is a major cause of cancer-related death

however, it was not significantly upregulated (Supplementary Fig

People with a prior history of gastrointestinal problems and aged individuals are more likely to suffer from intense stomach cramps and severe diarrhoea after taking high doses of vitamin B. Most people are able to get enough vitamin B12 from their diets, however, occasionally when running low, supplements or B12 injections may be recommended

This cascade ultimately leads to neuronal apoptosis and further aggravates cognitive impairment (82)