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Changes in the expression levels of non-coding small RNAs have been observed in various regions of the brains of patients with depression, including miR-484-5p, miR-26b-5p, miR-30d-5p, and miR-197-3p in the BA9 region

Short-term medicine use is sometimes considered as a supplement to behavioural interventions for patients who are not responding to CBT alone, or in those with severe symptoms at baseline

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Additionally, the use of multi-strain formulations or next-generation probiotics, such as Akkermansia muciniphila and Faecalibacterium prausnitzii , may offer superior anti-inflammatory effects and mucosal repair capacities, thus making them promising candidates for future clinical and preventive applications