glutathione iron sulfur cluster Mitochondrial iron-sulfur biogenesis from molecular understanding to clinical disease Iron–Sulfur Cluster Metabolism Impacts Iron
Description
Cell 112 , 481490 (2003)
Why the gradual approach
Curcumin-piperine treatment was frequently associated with reduced expression of inflammatory mediators, including TNF-, IL-1, IL-6, MCP-1, and GFAP, particularly in models of lipopolysaccharide-induced neuroinflammation and cuprizone-induced demyelination
There is very little blood-flow to this tissue in the body
One key process is glutamate excitotoxicity, where a buildup of glutamate at the synapse due to reduced function of the transporter EAAT2 (also known as GLT-1) leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors
