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Through these pathways, tumor cells can maintain their antioxidant ability and meet the needs of rapid proliferation ( 2.5 Metabolic heterogeneity and clonal evolution: the metabolic basis of tumor evolution Single-cell and spatialomics techniques revealed high metabolic heterogeneity in ccRCC, reflecting differences across tumor regions and cell subgroups (Table 1 further illustrates the key characteristics of each metabolic pathway and its therapeutic significance

Additionally, treatment of HCT116 cells with 5-FU and oxaliplatin slightly decreased p-AKT and p-p38 pathways in HCT116 cells while being prone to increasing p-AKT and p-p38 in HCT116 GSTA4 cells

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Low dietary creatine or high demand may increase this burden

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