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neoformans has four catalases, two superoxide dismutases, glutathione peroxidases, thioredoxin proteins, protein kinase C and the inositol phosphosphingolipid-phospholipase C1 to manage the oxidative environment inside the macrophages [124,125,126,127,128]

166 Besides, Ca 2+ overload activates calpain, which cleaves BCL-2 proteins and activates BID and AIF, thereby promoting apoptosis

Recent findings indicate that addictive drugs can induce persistent epigenetic remodeling in reward and stress-related pathways, changes that may contribute to the emotional dysregulation frequently observed during and after substance use 9,19

13 Additionally, exosomes derived from CTF1-modified bone marrow stem cells have been shown to mediate efficient repair of injured endometrial tissues by promoting enhanced angiogenesis and consequent improvements in endometrial receptivity

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