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Some of the aforementioned research has translated into clinical practice, with studies showing that combination of autophagy inducers with chemotherapeutic drugs enhanced their effectiveness (5254)

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2021;189 doi: 10.1016/j.bios.2021.113373

The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017)

Biomarkers, such as circulating miRNAs, even within extracellular vesicles, or markers of inflammasome activation could guide treatment selection and monitor therapeutic efficacy [56, 156]