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per oral [99,118,140,142,155,169,170,171,194,203,227,229,233,238,239,241,242,265,266,267,278,279,280,281,282,283,284,285,286]
Cuadrado and colleagues first showed that GSK-3 inhibits NRF2 activity, but the identification of sites in NRF2 that are phosphorylated by GSK-3 was achieved several years later using two-dimensional electrophoresis and mass spectrometry: GSK-3 phosphorylates a group of Ser residues at the level of DSGIS motif in the Neh6 domain of NRF2, and this event represents the signal for the recognition by the adapter protein -TrCP, that targets NRF2 for ubiquitination and proteasomal degradation in a KEAP1-independent manner [150, 151]
Inflammation is necessary to pathologic healing with macrophages playing a key role in modulating pulmonary fibrosis 21 and profibrotic signaling events 22,23
Despite the impressive success of immune checkpoint inhibitors across various tumor types, tumor cells can circumvent immune system attacks through several mechanisms, undermining the therapeutic potential of ICIs (183, 184)
2020 Dec 31:rs.3.rs-100914
