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Immediate effects of barrier compromise include increased water loss (your skin feels tight and dry despite moisturising), increased sensitivity to previously tolerated products, and compromised protection against bacteria and environmental irritants

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Further, Raman spectroscopy can enable identification of microbial dark matter, or previously uncultivated microbes, and sample measurement is non-invasive allowing for re-use in other experiments 170,171

However, RBCs still have a limited lifespan after which they are removed from circulation by the spleen and liver