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Interestingly, the stage of plaque macrophage progression depends on the intensity of monocyte myelopoiesis and macrophage proliferation, the increased expression of chemokines and the expression of several inhibitor molecules for migration within the plaque, including netrin-1 (142)

They provide a direct way to get B12, which is important for those with deficiency

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It lies adjacent to key structures such as the pituitary gland, optic chiasm, and ventricular system, which circulates cerebrospinal fluid (CSF)

They are primarily used to treat various forms of hypothyroidism, including post-thyroidectomy replacement, congenital thyroid hormone deficiency, and situations where levothyroxine monotherapy fails to relieve symptoms