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Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level
Such role has been shown from chromosomal mapping of the mouse GPX2 gene near the Ccs1 locus on chromosome 12, which contains a colon cancer susceptible gene
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This leakage further activates microglia towards the M1 phenotype, promoting release of neurotoxic agents, including TNF- and IL-6 (50)
The main difference consists in the molecular and cellular mechanisms of the therapeutic effects (210, 211)
